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Research

Comparative Genomics

Group Leader:



1997-2001 Junior researcher at the Molecular Biology and Biochemistry department at the Universitat de València (www.uv.es)

2001-2005 PhD in Bioinformatics, at CMBI (www.cmbi.ru.nl) and NCMLS (www.ncmls.ru.nl) centres at Nijmegen University (The Netherlands) (www.ru.nl) 

2005-2007 EMBO (www.embo.org) Postdoctoral fellow at the Bioinformatics Department at CIPF (Valencia). (http://bioinfo.cipf.es) 

2007-2008 FIS contracted researcher at the Bioinformatics Department at CIPF (Valencia). (http://bioinfo.cipf.es)  

Since Sept 2008 Junior Group Leader in the Bioinformatics and Genomics Programme, at the CRG (Barcelona) (www.crg.es)

Summary

Our research interests are focused around the use of comparative genomics and phylogenomics to study the origin, evolution and function of complex biological systems. This includes understanding how specific biochemical pathways, protein complexes or cellular organelles emerged and evolved as well as using this evolutionary information to gain insight into their function.

Through collaborations with experimental groups we apply comparative genomics to discover new mechanisms and genes involved in interesting processes, especially those of clinical relevance (see lines of research). On the technical side, our work often involves the development of new bioinformatics tools and algorithms that we make available to the community. 

You can have more details here.

http://gabaldonlab.cgenomics.org
http://gabaldonlab.crg.es
Research Lines
Comparative genomics of fungal pathogens
Discovery of new genes involved in mitochondrial-related diseases
Comparative genomics of apoptosis and other eukaryotic programmed cell death pathways
Origin and evolution of eukaryotic organelles such as mitochondria and peroxisome.
Phylogenomics and genome evolution through large-scale phylogenetics
Other Activities
http://phylomedb.cgenomics.org
http://trimal.cgenomics.org
http://phylemon.bioinfo.cipf.es
Selected Publications

Mihailovich M, Militti C, Gabaldón T, Gebauer F..
Eukaryotic cold shock domain proteins: highly versatile regulators of gene expression.
Bioessays. Feb;32(2):109-18. (2010). PubMed ID: 20091748.abstract
Huerta-Cepas J, Bueno A, Dopazo J, Gabaldón T..
PhylomeDB: a database for genome-wide collections of gene phylogenies
Nucleic Acids Res. 2008 Jan;36(Database issue):D491-6 (2008). abstract
Huerta-Cepas J, Dopazo H, Dopazo J, Gabaldón T..
The human phylome.
Genome Biol. 2007;8(6):R109 (2007). abstract
Boxma B, de Graaf RM, van der Staay GW, van Alen TA, Ricard G, Gabaldón T, van Hoek AH, Moon-van der Staay SY et al.
An anaerobic mitochondrion that produces hydrogen
Nature. 2005 Mar 3;434(7029):74-9. (2005). abstract
Gabaldón T, Huynen MA..
Reconstruction of the proto-mitochondrial metabolism.
Science 2003 Aug 1;301(5633):609 (2003). abstract

 
 
 

Group Members