PRBB-CRG Sessions
Scientific sessions of the PRBB centres funded by the Centre for Genomic Regulation (CRG) and the Barcelona Biomedical Research Park
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10/05/202412:00PRBB AuditoriumPRBB-CRG SessionsSteven GygiHarvard Medical School"Proteomics as a biological assay"Host: Eduard SabidoAbstract:Proteomics is the systematic analysis of proteins for their various properties including expression levels, modification state, structure, interaction partners, function, and many more. For protein expression profiling, the combination of mass spectrometry with sample multiplexing creates a unique biological assay where replicates, positive and negative controls, as well as all treatment conditions can be measured in a single experiment. Tandem mass tags (TMT) facilitate these analyses and will soon be...
17/05/202412:00MARIE CURIEPRBB-CRG SessionsFrank BradkeDZNE German Center for Neurodegenerative Diseases"Mechanisms of Axon Growth and Regeneration"Host: Thomas SurreyAbstract:Almost everybody who has seen neurons under a microscope for the first time is fascinated by their beauty and their complex shape. Early on during development, however, neurons look round and simple without signs of their future complexity. How do neurons develop their sophisticated structure? How do they initially generate domains that later have distinct functions within neuronal circuits, such as the axon? And, can a...
24/05/202412:00MARIE CURIEPRBB-CRG SessionsHarris LewinUniversity of California Davis & Arizona State University"A Dive into the Breakpoints of Evolution"Host: Roderic GuigóAbstract:Chromosome rearrangements occurring during evolution drive speciation; some are adaptive and positively selected. My laboratory has studied chromosome evolution in mammals for 30 years and developed powerful tools to detect, visualize, and analyze chromosome rearrangements at high resolution. Advances in producing annotated chromosome-scale whole genome assemblies de novo, have led to dramatic improvements in our understanding of chromosome evolution and the genomic...
07/06/202412:00MARIE CURIEPRBB-CRG SessionsArnaud KrebsEuropean Molecular Biology Laboratory (EMBL)"Cooperativity and antagonisms in transcription regulation"Host: Renee BeekmanAbstract:Transcription factors (TFs) bind at cis-regulatory elements (CREs) such as enhancers and promoters to activate transcription. In higher eukaryotes, chromatin presents a physical barrier that needs to be overcomed by TFs to access their DNA recognition motifs and activate transcription. Cooperativity is assumed to be a key mechanism for TFs to outcompete nucleosomes. Yet, the contribution of individual TFs to chromatin accessibility at CREs, and how their functions are assembled is currently...
14/06/202412:00MARIE CURIEPRBB-CRG SessionsJan LammerdingMeinig School of Biomedical Engineering, Cornell University"tbc"Host: Verena Ruprecht
21/06/202412:00MARIE CURIEPRBB-CRG SessionsFrancis ImpensVIB & Ghent University"Host-bacteria proteomics: from antibacterial PTMs to vaccine development"Host: Eduard SabidóAbstract:The Impens lab at VIB & Ghent University, Belgium, aims to better understand the fundamental principles of host-bacteria interactions using innovative mass spectrometry (MS)-based approaches. Using Listeria monocytogenes as an intracellular bacterial model pathogen, the seminar will cover the lab’s progress to characterize protein modification by ISG15 and to develop mRNA vaccines against bacterial pathogens. ISG15 is a ubiquitin-like modification of the immune system that counteracts...
21/06/202414:30PRBB AuditoriumPRBB-CRG SessionsKazutoshi MoriInstitute for Advanced Science, Kyoto University"Dynamics of the Function and Regulation of the Endoplasmic Reticulum"Host: Vivek MalhotraAbstract:Protein unfolding and misfolding constitute a fundamental threat to all living cells. In eukaryotes, the risk of misfolding is particularly high in the endoplasmic reticulum (ER), where newly synthesized secretory and transmembrane proteins destined for the secretory pathway achieve their proper tertiary and quaternary structure. These proteins are critical for intercellular communication and their quality is maintained by chaperone-mediated productive folding...
28/06/202412:00MARIE CURIEPRBB-CRG SessionsMagda BienkoHuman Technopole and Karolinska Institute"Long-distance communication between long and short neuronal genes mediated by RNA"Host: Renée Beekman & Victoria NeguemborAbstract:Intronic sequences are spliced out of newly transcribed RNAs and are usually rapidly degraded. Because of their rapid degradation, intronic RNAs have been classically viewed as splicing by-products. Here, we integrate genome-wide maps of RNA-DNA contacts measured by RADICL-seq with genome radiality maps obtained by GPSeq, to illuminate the spatial distribution and fate of intronic RNAs in the...
05/07/202412:00MARIE CURIEPRBB-CRG SessionsAndrea CossarizzaUniversità degli Studi di Modena e Reggio Emilia"Single-cell analysis of immunometabolism: a new lens to understand human diseases"Host: Oscar FornasAbstract:In the last years, it has become more and more evident that different metabolic profiles in immune cells explain different functions, and even clinical outcomes. Importantly, to investigate the so called immunometabolism, several approaches and techniques can now be used that include spectral and mass cytometry, multiparametric cell sorting and single cell RNA sequencing, among others. In my talk, taking advantage from the aforementioned...
12/07/202412:00MARIE CURIEPRBB-CRG SessionsMaurizio ScaltritiAstraZeneca, Oncology R&D"tbc"Host: Luciano di Croce